Steroid Conversion Calculator

Corticosteroids vary significantly in their anti-inflammatory potency and duration of action. To convert safely, all calculations reference a baseline drug, typically hydrocortisone or prednisone. The underlying formula multiplies the initial dose by the ratio of the target steroid's relative potency compared to the source steroid. For instance, because hydrocortisone has a short biological half-life and weaker potency compared to dexamethasone, transitioning requires scaling the milligram dose downward to prevent toxicity or adverse metabolic side effects.

Imagine a patient currently taking 100 mg of cortisone daily who needs to be transitioned to an equivalent dose of dexamethasone. First, we convert cortisone to our baseline hydrocortisone equivalent, noting that cortisone is slightly less potent than hydrocortisone (100 mg cortisone equals 80 mg hydrocortisone). Next, applying the dexamethasone conversion factor where dexamethasone equals hydrocortisone multiplied by 0.0375: 80 mg multiplied by 0.0375 yields exactly 3 mg of dexamethasone daily. This step-by-step ratio scaling guarantees that the patient receives an identical therapeutic anti-inflammatory effect without an accidental overdose.

Always account for individual patient sensitivities and underlying medical conditions when switching steroid types, as potency equivalency does not automatically predict mineralocorticoid side effects. When converting high doses over extended periods, consult a qualified medical professional to implement a proper tapering schedule and avoid acute adrenal insufficiency. Double-check all mathematical conversions, particularly when working with highly potent agents like dexamethasone or betamethasone where minor dosing errors carry significant clinical consequences.